相互作用
Acalabrutinib + Aluminum hydroxide
重症度: 中等度
Acalabrutinib and Aluminum hydroxide: moderate interaction.
最終更新日
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概要
Antacids neutralise gastric acid and can lower the dissolution and absorption of acalabrutinib capsules. Reduced exposure may weaken its antitumor effect.
この相互作用をわかりやすく説明すると
Acalabrutinib and Aluminum hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acalabrutinib belongs to Oncology; Aluminum hydroxide belongs to Gastrointestinal Tract.
なぜ起こるのか
Increased gastric pH reduces the pH-dependent solubility of acalabrutinib.
対処法
Separate the antacid and acalabrutinib capsules by at least 2 hours, or use the pH-independent tablet formulation.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AcalabrutinibとAluminum hydroxideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Aluminum hydroxideのその他の相互作用
Acalabrutinibのその他の相互作用
よくある質問
Can I take Acalabrutinib with Aluminum hydroxide?
MediHelp rates the interaction as moderate. Acalabrutinib and Aluminum hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids neutralise gastric acid and can lower the dissolution and absorption of acalabrutinib capsules. Reduced exposure may weaken its antitumor effect.
How serious is the interaction between Acalabrutinib and Aluminum hydroxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate the antacid and acalabrutinib capsules by at least 2 hours, or use the pH-independent tablet formulation.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
