相互作用
Acitretin + Norethindrone
重症度: 併用禁忌
Acitretin and Norethindrone: contraindicated interaction.
最終更新日
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概要
Acitretin has been reported to interfere with progestin-only contraceptives, such as minipills, reducing their effectiveness. Since acitretin is highly teratogenic, any contraceptive failure is serious. Labeling advises against progestin-only pills in this setting.
この相互作用をわかりやすく説明すると
Acitretin and Norethindrone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Mechanism unclear; acitretin may reduce the contraceptive efficacy of low-dose progestins.
対処法
Do not rely on norethindrone-only contraception during acitretin therapy. Use two reliable contraceptive methods, such as a combined hormonal method plus a barrier method, as advised by labeling.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AcitretinとNorethindroneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Acitretinのその他の相互作用
よくある質問
Can I take Acitretin with Norethindrone?
MediHelp rates the interaction as contraindicated. Acitretin and Norethindrone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Acitretin has been reported to interfere with progestin-only contraceptives, such as minipills, reducing their effectiveness. Since acitretin is highly teratogenic, any contraceptive failure is serious. Labeling advises against progestin-only pills in this setting.
How serious is the interaction between Acitretin and Norethindrone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not rely on norethindrone-only contraception during acitretin therapy. Use two reliable contraceptive methods, such as a combined hormonal method plus a barrier method, as advised by labeling.
What other medicines interact with Acitretin?
MediHelp also lists interactions of Acitretin with, for example, Demeclocycline, Doxycycline, Ethanol. The full list is on the Acitretin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
