相互作用
Adenovirus types 4 and 7 live + Paclitaxel
重症度: 重大
Adenovirus types 4 and 7 live and Paclitaxel: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Paclitaxel is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine may cause disseminated vaccine-strain infection. The immune response to the vaccine may also be diminished.
この相互作用をわかりやすく説明すると
Adenovirus types 4 and 7 live and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Chemotherapy-induced immunosuppression impairs control of live attenuated virus replication and reduces vaccine immunogenicity.
対処法
Avoid the live vaccine during paclitaxel therapy and for at least 3 months after it ends. Consider vaccinating only after immune recovery.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Adenovirus types 4 and 7 liveとPaclitaxelの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Paclitaxelのその他の相互作用
よくある質問
Can I take Adenovirus types 4 and 7 live with Paclitaxel?
MediHelp rates the interaction as major. Adenovirus types 4 and 7 live and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Paclitaxel is myelosuppressive and immunosuppressive, so a live oral adenovirus vaccine may cause disseminated vaccine-strain infection. The immune response to the vaccine may also be diminished.
How serious is the interaction between Adenovirus types 4 and 7 live and Paclitaxel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live vaccine during paclitaxel therapy and for at least 3 months after it ends. Consider vaccinating only after immune recovery.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Cobicistat, Cyclosporine, Cyclosporin. The full list is on the Paclitaxel page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
