相互作用
Ado-trastuzumab + Deferiprone
重症度: 重大
Ado-trastuzumab and Deferiprone: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Deferiprone can cause neutropenia and agranulocytosis, and ado-trastuzumab emtansine also causes myelosuppression. Combined use may increase the risk of severe infections from low neutrophil counts.
この相互作用をわかりやすく説明すると
Ado-trastuzumab and Deferiprone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ado-trastuzumab belongs to Oncology; Deferiprone belongs to Miscellaneous.
なぜ起こるのか
Additive myelosuppressive effects (pharmacodynamic).
対処法
Avoid the combination if an alternative chelator is possible. Otherwise monitor absolute neutrophil count and platelets more frequently.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Ado-trastuzumabとDeferiproneの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Ado-trastuzumabのその他の相互作用
Deferiproneのその他の相互作用
よくある質問
Can I take Ado-trastuzumab with Deferiprone?
MediHelp rates the interaction as major. Ado-trastuzumab and Deferiprone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferiprone can cause neutropenia and agranulocytosis, and ado-trastuzumab emtansine also causes myelosuppression. Combined use may increase the risk of severe infections from low neutrophil counts.
How serious is the interaction between Ado-trastuzumab and Deferiprone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative chelator is possible. Otherwise monitor absolute neutrophil count and platelets more frequently.
What other medicines interact with Ado-trastuzumab?
MediHelp also lists interactions of Ado-trastuzumab with, for example, Atazanavir, Baricitinib, Ceritinib. The full list is on the Ado-trastuzumab page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
