相互作用
Alemtuzumab + Denosumab
重症度: 中等度
Alemtuzumab and Denosumab: moderate interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Alemtuzumab causes profound, prolonged lymphocyte depletion, and denosumab has been linked to serious infections. The combination may increase the risk of serious or opportunistic infection.
この相互作用をわかりやすく説明すると
Alemtuzumab and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alemtuzumab belongs to Miscellaneous; Denosumab belongs to Oncology.
なぜ起こるのか
Additive immunosuppression from profound lymphocyte depletion by alemtuzumab and RANKL inhibition by denosumab.
対処法
Monitor closely for infection during and after alemtuzumab, and consider whether denosumab can be timed or deferred. Start prompt evaluation of any fever or infectious symptoms.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AlemtuzumabとDenosumabの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Denosumabのその他の相互作用
Alemtuzumabのその他の相互作用
よくある質問
Can I take Alemtuzumab with Denosumab?
MediHelp rates the interaction as moderate. Alemtuzumab and Denosumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alemtuzumab causes profound, prolonged lymphocyte depletion, and denosumab has been linked to serious infections. The combination may increase the risk of serious or opportunistic infection.
How serious is the interaction between Alemtuzumab and Denosumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for infection during and after alemtuzumab, and consider whether denosumab can be timed or deferred. Start prompt evaluation of any fever or infectious symptoms.
What other medicines interact with Denosumab?
MediHelp also lists interactions of Denosumab with, for example, Abatacept, Adalimumab, Alefacept. The full list is on the Denosumab page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
