相互作用
Amantadine + Trospium
重症度: 中等度
Amantadine and Trospium: moderate interaction.
最終更新日
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概要
Amantadine has anticholinergic properties and may add to the antimuscarinic effects of trospium. This can cause dry mouth, constipation, urinary retention and confusion, particularly in older adults. Because both drugs are renally eliminated, impaired renal function can also raise exposure.
この相互作用をわかりやすく説明すると
Amantadine and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amantadine belongs to Anti Virals; Trospium belongs to Genitourinary.
なぜ起こるのか
Additive anticholinergic effects; both drugs are also renally cleared and may compete for tubular secretion.
対処法
Monitor for anticholinergic effects and cognitive changes, and check renal function. Reduce doses if adverse effects appear.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AmantadineとTrospiumの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Trospiumのその他の相互作用
Amantadineのその他の相互作用
よくある質問
Can I take Amantadine with Trospium?
MediHelp rates the interaction as moderate. Amantadine and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amantadine has anticholinergic properties and may add to the antimuscarinic effects of trospium. This can cause dry mouth, constipation, urinary retention and confusion, particularly in older adults. Because both drugs are renally eliminated, impaired renal function can also raise exposure.
How serious is the interaction between Amantadine and Trospium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and cognitive changes, and check renal function. Reduce doses if adverse effects appear.
What other medicines interact with Trospium?
MediHelp also lists interactions of Trospium with, for example, Clozapine, Pramlintide, Thioridazine. The full list is on the Trospium page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
