相互作用
Anagrelide + Entrectinib
重症度: 重大
Anagrelide and Entrectinib: major interaction.
最終更新日
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概要
Entrectinib can prolong the QTc interval, and anagrelide adds a similar effect, so the combination increases the risk of serious ventricular arrhythmias. Patients with bradycardia, heart failure or electrolyte disturbances are at greater risk.
この相互作用をわかりやすく説明すると
Anagrelide and Entrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Entrectinib belongs to Oncology.
なぜ起こるのか
Additive pharmacodynamic prolongation of the QT interval.
対処法
Avoid the combination where an alternative exists. If it cannot be avoided, monitor ECG and electrolytes and adjust or hold entrectinib per labeling for significant QTc prolongation.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AnagrelideとEntrectinibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Anagrelideのその他の相互作用
Entrectinibのその他の相互作用
よくある質問
Can I take Anagrelide with Entrectinib?
MediHelp rates the interaction as major. Anagrelide and Entrectinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Entrectinib can prolong the QTc interval, and anagrelide adds a similar effect, so the combination increases the risk of serious ventricular arrhythmias. Patients with bradycardia, heart failure or electrolyte disturbances are at greater risk.
How serious is the interaction between Anagrelide and Entrectinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists. If it cannot be avoided, monitor ECG and electrolytes and adjust or hold entrectinib per labeling for significant QTc prolongation.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
