相互作用
Andexanet alfa + Heparin
重症度: 重大
Andexanet alfa and Heparin: major interaction.
最終更新日
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概要
After andexanet alfa, unfractionated heparin may be unresponsive, with activated clotting times not prolonging as expected. This can lead to inadequate anticoagulation, for example during procedures.
この相互作用をわかりやすく説明すると
Andexanet alfa and Heparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Andexanet alfa belongs to Cardiovascular; Heparin belongs to Cardiovascular.
なぜ起こるのか
Andexanet alfa binds heparin-antithrombin complexes, neutralizing heparin's anticoagulant effect.
対処法
Do not use unfractionated heparin after andexanet alfa; select an alternative anticoagulant if one is needed.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Andexanet alfaとHeparinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Heparinのその他の相互作用
よくある質問
Can I take Andexanet alfa with Heparin?
MediHelp rates the interaction as major. Andexanet alfa and Heparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. After andexanet alfa, unfractionated heparin may be unresponsive, with activated clotting times not prolonging as expected. This can lead to inadequate anticoagulation, for example during procedures.
How serious is the interaction between Andexanet alfa and Heparin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use unfractionated heparin after andexanet alfa; select an alternative anticoagulant if one is needed.
What other medicines interact with Heparin?
MediHelp also lists interactions of Heparin with, for example, Defibrotide, Ketorolac, Oritavancin. The full list is on the Heparin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
