相互作用
Ascorbic acid + Deferoxamine
重症度: 重大
Ascorbic acid and Deferoxamine: major interaction.
最終更新日
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概要
Vitamin C mobilizes storage iron and makes more of it available for chelation by deferoxamine, increasing iron excretion. In iron-overloaded patients, especially with cardiac disease, high-dose vitamin C has been linked to cardiac decompensation and arrhythmia.
この相互作用をわかりやすく説明すると
Ascorbic acid and Deferoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Ascorbic acid increases the pool of chelatable iron, and the redox-active iron released may cause cardiac toxicity.
対処法
Avoid ascorbic acid in patients with cardiac dysfunction on deferoxamine. If used in others, start only after deferoxamine is established, keep doses low and give it with the infusion, with cardiac monitoring.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Ascorbic acidとDeferoxamineの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Deferoxamineのその他の相互作用
よくある質問
Can I take Ascorbic acid with Deferoxamine?
MediHelp rates the interaction as major. Ascorbic acid and Deferoxamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vitamin C mobilizes storage iron and makes more of it available for chelation by deferoxamine, increasing iron excretion. In iron-overloaded patients, especially with cardiac disease, high-dose vitamin C has been linked to cardiac decompensation and arrhythmia.
How serious is the interaction between Ascorbic acid and Deferoxamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ascorbic acid in patients with cardiac dysfunction on deferoxamine. If used in others, start only after deferoxamine is established, keep doses low and give it with the infusion, with cardiac monitoring.
What other medicines interact with Deferoxamine?
MediHelp also lists interactions of Deferoxamine with, for example, Betibeglogene autotemcel, Exagamglogene autotemcel, Lovotibeglogene autotemcel. The full list is on the Deferoxamine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
