相互作用
Asenapine + Encorafenib
重症度: 重大
Asenapine and Encorafenib: major interaction.
最終更新日
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概要
Encorafenib can prolong the QTc interval in a dose-dependent manner, and asenapine has a similar effect. Used together they may increase the risk of torsades de pointes.
この相互作用をわかりやすく説明すると
Asenapine and Encorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Encorafenib belongs to Oncology.
なぜ起こるのか
Additive QT interval prolongation.
対処法
Avoid the combination where possible. If it is needed, monitor ECG and electrolytes at baseline and periodically, and reduce or withhold encorafenib if QTc becomes markedly prolonged.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、AsenapineとEncorafenibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Asenapineのその他の相互作用
Encorafenibのその他の相互作用
よくある質問
Can I take Asenapine with Encorafenib?
MediHelp rates the interaction as major. Asenapine and Encorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Encorafenib can prolong the QTc interval in a dose-dependent manner, and asenapine has a similar effect. Used together they may increase the risk of torsades de pointes.
How serious is the interaction between Asenapine and Encorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is needed, monitor ECG and electrolytes at baseline and periodically, and reduce or withhold encorafenib if QTc becomes markedly prolonged.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
