相互作用
Aspirin / citric acid / sodium bicarbonate + Deferasirox
重症度: 重大
Aspirin / citric acid / sodium bicarbonate and Deferasirox: major interaction.
最終更新日
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概要
The aspirin component adds gastric mucosal injury and antiplatelet effect to the ulcer and hemorrhage risk already associated with deferasirox. Bleeding risk is therefore increased.
この相互作用をわかりやすく説明すると
Aspirin / citric acid / sodium bicarbonate and Deferasirox can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive GI mucosal injury plus aspirin-induced platelet inhibition.
対処法
Avoid the combination if possible and use a non-NSAID analgesic instead. If aspirin is needed, add gastroprotection and monitor for GI bleeding.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Aspirin / citric acid / sodium bicarbonateとDeferasiroxの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Deferasiroxのその他の相互作用
よくある質問
Can I take Aspirin / citric acid / sodium bicarbonate with Deferasirox?
MediHelp rates the interaction as major. Aspirin / citric acid / sodium bicarbonate and Deferasirox can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The aspirin component adds gastric mucosal injury and antiplatelet effect to the ulcer and hemorrhage risk already associated with deferasirox. Bleeding risk is therefore increased.
How serious is the interaction between Aspirin / citric acid / sodium bicarbonate and Deferasirox?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use a non-NSAID analgesic instead. If aspirin is needed, add gastroprotection and monitor for GI bleeding.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
