相互作用
Basiliximab + Ciltacabtagene autoleucel
重症度: 重大
Basiliximab and Ciltacabtagene autoleucel: major interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Basiliximab blocks IL-2 receptor on activated T cells, which could impair expansion and activity of CAR T cells and weaken efficacy. It also adds to infection risk after lymphodepletion.
この相互作用をわかりやすく説明すると
Basiliximab and Ciltacabtagene autoleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Basiliximab belongs to Miscellaneous; Ciltacabtagene autoleucel belongs to Miscellaneous.
なぜ起こるのか
Pharmacodynamic antagonism of CAR T-cell proliferation through IL-2 receptor blockade and additive immunosuppression.
対処法
Avoid basiliximab around CAR T infusion unless clearly needed; coordinate with the treating oncology team and monitor for infection.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BasiliximabとCiltacabtagene autoleucelの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Basiliximabのその他の相互作用
- Basiliximab + Bcg vaccine live 併用禁忌
- Basiliximab + Influenza virus vaccine quadrivalent intranasal 併用禁忌
- Basiliximab + Measles mumps and rubella vaccine 併用禁忌
- Basiliximab + Measles mumps and rubella vaccine live 併用禁忌
- Basiliximab + Measles mumps rubella and varicella vaccine live 併用禁忌
- Basiliximab + Measles vaccine 併用禁忌
Ciltacabtagene autoleucelのその他の相互作用
よくある質問
Can I take Basiliximab with Ciltacabtagene autoleucel?
MediHelp rates the interaction as major. Basiliximab and Ciltacabtagene autoleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Basiliximab blocks IL-2 receptor on activated T cells, which could impair expansion and activity of CAR T cells and weaken efficacy. It also adds to infection risk after lymphodepletion.
How serious is the interaction between Basiliximab and Ciltacabtagene autoleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid basiliximab around CAR T infusion unless clearly needed; coordinate with the treating oncology team and monitor for infection.
What other medicines interact with Basiliximab?
MediHelp also lists interactions of Basiliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Basiliximab page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
