相互作用
Betrixaban + Celecoxib
重症度: 重大
Betrixaban and Celecoxib: major interaction.
最終更新日
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概要
Celecoxib impairs platelet function and can injure the gastric mucosa, while betrixaban is an oral factor Xa inhibitor. Together they raise the risk of significant bleeding, especially gastrointestinal.
この相互作用をわかりやすく説明すると
Betrixaban and Celecoxib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Additive pharmacodynamic effect: NSAID antiplatelet activity and mucosal injury combined with factor Xa inhibition.
対処法
Avoid concurrent NSAID use when possible and use acetaminophen instead. If combined, monitor for bleeding and hemoglobin and consider gastroprotection.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、BetrixabanとCelecoxibの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Celecoxibのその他の相互作用
よくある質問
Can I take Betrixaban with Celecoxib?
MediHelp rates the interaction as major. Betrixaban and Celecoxib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Celecoxib impairs platelet function and can injure the gastric mucosa, while betrixaban is an oral factor Xa inhibitor. Together they raise the risk of significant bleeding, especially gastrointestinal.
How serious is the interaction between Betrixaban and Celecoxib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent NSAID use when possible and use acetaminophen instead. If combined, monitor for bleeding and hemoglobin and consider gastroprotection.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
