相互作用
Carbamazepine + Dienogest / estradiol valerate
重症度: 併用禁忌
Carbamazepine and Dienogest / estradiol valerate: contraindicated interaction.
最終更新日
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概要
Carbamazepine induces hepatic metabolism of estrogens and progestins and can reduce contraceptive efficacy, causing breakthrough bleeding and unintended pregnancy. Labeling advises against use with strong inducers and for a period after stopping.
この相互作用をわかりやすく説明すると
Carbamazepine and Dienogest / estradiol valerate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Carbamazepine induces CYP3A4, accelerating metabolism of dienogest and estradiol.
対処法
Use a non-hormonal or inducer-independent contraceptive such as a copper IUD or DMPA, and continue it for about 28 days after stopping carbamazepine.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CarbamazepineとDienogest / estradiol valerateの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Carbamazepineのその他の相互作用
よくある質問
Can I take Carbamazepine with Dienogest / estradiol valerate?
MediHelp rates the interaction as contraindicated. Carbamazepine and Dienogest / estradiol valerate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Carbamazepine induces hepatic metabolism of estrogens and progestins and can reduce contraceptive efficacy, causing breakthrough bleeding and unintended pregnancy. Labeling advises against use with strong inducers and for a period after stopping.
How serious is the interaction between Carbamazepine and Dienogest / estradiol valerate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-hormonal or inducer-independent contraceptive such as a copper IUD or DMPA, and continue it for about 28 days after stopping carbamazepine.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
