相互作用
Ceritinib + Solifenacin
重症度: 重大
Ceritinib and Solifenacin: major interaction.
最終更新日
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概要
Ceritinib prolongs the QT interval and inhibits CYP3A4, which raises solifenacin exposure. This increases the risk of QT-related arrhythmia.
この相互作用をわかりやすく説明すると
Ceritinib and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Solifenacin belongs to Genitourinary.
なぜ起こるのか
Additive QT prolongation plus CYP3A4 inhibition by ceritinib that raises solifenacin concentrations.
対処法
Avoid the combination and choose another bladder agent. If it cannot be avoided, limit solifenacin to 5 mg daily and monitor ECG and electrolytes.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CeritinibとSolifenacinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Solifenacinのその他の相互作用
Ceritinibのその他の相互作用
よくある質問
Can I take Ceritinib with Solifenacin?
MediHelp rates the interaction as major. Ceritinib and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceritinib prolongs the QT interval and inhibits CYP3A4, which raises solifenacin exposure. This increases the risk of QT-related arrhythmia.
How serious is the interaction between Ceritinib and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another bladder agent. If it cannot be avoided, limit solifenacin to 5 mg daily and monitor ECG and electrolytes.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
