相互作用
Cidofovir + Cyclosporin
重症度: 併用禁忌
Cidofovir and Cyclosporin: contraindicated interaction.
最終更新日
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概要
Cidofovir causes proximal tubular injury and can lead to acute kidney failure. Cyclosporine causes dose-related renal vasoconstriction and nephrotoxicity, so combining them compounds the risk of renal damage.
この相互作用をわかりやすく説明すると
Cidofovir and Cyclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cidofovir belongs to Anti Virals; Cyclosporin belongs to Miscellaneous.
なぜ起こるのか
Additive nephrotoxicity (cidofovir proximal tubule uptake via OAT1 plus partner renal toxicity)
対処法
Avoid concurrent use or stop the other nephrotoxin at least 7 days before cidofovir where feasible; if unavoidable give probenecid and saline pre-hydration per the cidofovir protocol and monitor creatinine and urine protein before each dose.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CidofovirとCyclosporinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Cyclosporinのその他の相互作用
Cidofovirのその他の相互作用
よくある質問
Can I take Cidofovir with Cyclosporin?
MediHelp rates the interaction as contraindicated. Cidofovir and Cyclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cidofovir causes proximal tubular injury and can lead to acute kidney failure. Cyclosporine causes dose-related renal vasoconstriction and nephrotoxicity, so combining them compounds the risk of renal damage.
How serious is the interaction between Cidofovir and Cyclosporin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use or stop the other nephrotoxin at least 7 days before cidofovir where feasible; if unavoidable give probenecid and saline pre-hydration per the cidofovir protocol and monitor creatinine and urine protein before each dose.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
