相互作用
Clindamycin + Rapacuronium
重症度: 重大
Clindamycin and Rapacuronium: major interaction.
最終更新日
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概要
Clindamycin has intrinsic neuromuscular blocking activity and can potentiate non-depolarizing neuromuscular blockers. This may prolong paralysis and cause delayed respiratory depression. Rapacuronium has been withdrawn from the market in most countries, so this is mainly of historical relevance.
この相互作用をわかりやすく説明すると
Clindamycin and Rapacuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Clindamycin has additive pre- and postsynaptic neuromuscular blocking effects that potentiate non-depolarizing blockade.
対処法
Avoid the combination where possible. If a neuromuscular blocker and clindamycin must be given together, use quantitative neuromuscular monitoring and have ventilatory support available until full recovery is confirmed.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、ClindamycinとRapacuroniumの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Clindamycinのその他の相互作用
よくある質問
Can I take Clindamycin with Rapacuronium?
MediHelp rates the interaction as major. Clindamycin and Rapacuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clindamycin has intrinsic neuromuscular blocking activity and can potentiate non-depolarizing neuromuscular blockers. This may prolong paralysis and cause delayed respiratory depression. Rapacuronium has been withdrawn from the market in most countries, so this is mainly of historical relevance.
How serious is the interaction between Clindamycin and Rapacuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If a neuromuscular blocker and clindamycin must be given together, use quantitative neuromuscular monitoring and have ventilatory support available until full recovery is confirmed.
What other medicines interact with Clindamycin?
MediHelp also lists interactions of Clindamycin with, for example, Atracurium, Cisatracurium, Microbiota. The full list is on the Clindamycin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
