相互作用
Cobicistat + Lovastatin
重症度: 併用禁忌
Cobicistat and Lovastatin: contraindicated interaction.
最終更新日
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概要
Cobicistat is a potent CYP3A4 inhibitor and greatly increases lovastatin exposure, creating a high risk of myopathy and rhabdomyolysis. The combination is contraindicated.
この相互作用をわかりやすく説明すると
Cobicistat and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobicistat belongs to Miscellaneous; Lovastatin belongs to Cardiovascular.
なぜ起こるのか
Cobicistat inhibits CYP3A4, blocking lovastatin metabolism.
対処法
Do not coadminister. Switch to pravastatin or rosuvastatin and titrate carefully.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CobicistatとLovastatinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Lovastatinのその他の相互作用
Cobicistatのその他の相互作用
よくある質問
Can I take Cobicistat with Lovastatin?
MediHelp rates the interaction as contraindicated. Cobicistat and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat is a potent CYP3A4 inhibitor and greatly increases lovastatin exposure, creating a high risk of myopathy and rhabdomyolysis. The combination is contraindicated.
How serious is the interaction between Cobicistat and Lovastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Switch to pravastatin or rosuvastatin and titrate carefully.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Conivaptan. The full list is on the Lovastatin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
