相互作用
Cyclosporine + Rifaximin
重症度: 中等度
Cyclosporine and Rifaximin: moderate interaction.
最終更新日
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概要
Cyclosporine strongly inhibits P-glycoprotein and caused very large increases in rifaximin systemic exposure in healthy volunteers. This could matter in patients with impaired gut barrier or liver disease, where rifaximin exposure is already higher.
この相互作用をわかりやすく説明すると
Cyclosporine and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
なぜ起こるのか
Cyclosporine inhibition of P-glycoprotein markedly increases rifaximin absorption.
対処法
Use together only if the benefit justifies it and monitor for rifaximin adverse effects. Avoid or reassess in patients with severe hepatic impairment.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、CyclosporineとRifaximinの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Rifaximinのその他の相互作用
よくある質問
Can I take Cyclosporine with Rifaximin?
MediHelp rates the interaction as moderate. Cyclosporine and Rifaximin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine strongly inhibits P-glycoprotein and caused very large increases in rifaximin systemic exposure in healthy volunteers. This could matter in patients with impaired gut barrier or liver disease, where rifaximin exposure is already higher.
How serious is the interaction between Cyclosporine and Rifaximin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only if the benefit justifies it and monitor for rifaximin adverse effects. Avoid or reassess in patients with severe hepatic impairment.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
