相互作用
Dasatinib + Lansoprazole
重症度: 重大
Dasatinib and Lansoprazole: major interaction.
最終更新日
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このページの臨床コンテンツは英語でのみ提供されています。
概要
Dasatinib solubility is pH-dependent, and PPIs significantly reduce its absorption and exposure, which may compromise treatment of leukemia.
この相互作用をわかりやすく説明すると
Dasatinib and Lansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Lansoprazole belongs to Gastrointestinal Tract.
なぜ起こるのか
Raised gastric pH reduces dissolution and absorption of dasatinib.
対処法
Avoid PPIs with dasatinib. Use a short-acting antacid given at least 2 hours before or after dasatinib, or an H2 blocker timed carefully, if acid suppression is needed.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DasatinibとLansoprazoleの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Lansoprazoleのその他の相互作用
Dasatinibのその他の相互作用
よくある質問
Can I take Dasatinib with Lansoprazole?
MediHelp rates the interaction as major. Dasatinib and Lansoprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib solubility is pH-dependent, and PPIs significantly reduce its absorption and exposure, which may compromise treatment of leukemia.
How serious is the interaction between Dasatinib and Lansoprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with dasatinib. Use a short-acting antacid given at least 2 hours before or after dasatinib, or an H2 blocker timed carefully, if acid suppression is needed.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
