相互作用
Dengue vaccine + Pemetrexed
重症度: 重大
Dengue vaccine and Pemetrexed: major interaction.
最終更新日
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概要
Dengue vaccine is a live attenuated vaccine. Pemetrexed is a cytotoxic antimetabolite that suppresses immunity, which may reduce the vaccine response and raise the risk of vaccine-related infection.
この相互作用をわかりやすく説明すると
Dengue vaccine and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
なぜ起こるのか
Immunosuppression from cytotoxic chemotherapy blunts vaccine response and permits uncontrolled replication of live attenuated virus.
対処法
Avoid live vaccines during pemetrexed therapy and for a period after recovery of immune function as specified by local guidance. Vaccinate before starting chemotherapy where possible.
薬剤師に尋ねること
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Dengue vaccineとPemetrexedの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Pemetrexedのその他の相互作用
よくある質問
Can I take Dengue vaccine with Pemetrexed?
MediHelp rates the interaction as major. Dengue vaccine and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine is a live attenuated vaccine. Pemetrexed is a cytotoxic antimetabolite that suppresses immunity, which may reduce the vaccine response and raise the risk of vaccine-related infection.
How serious is the interaction between Dengue vaccine and Pemetrexed?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during pemetrexed therapy and for a period after recovery of immune function as specified by local guidance. Vaccinate before starting chemotherapy where possible.
What other medicines interact with Pemetrexed?
MediHelp also lists interactions of Pemetrexed with, for example, Bacitracin, Brexucabtagene autoleucel, Celecoxib. The full list is on the Pemetrexed page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
