相互作用
Didanosine + Hydroxyurea
重症度: 併用禁忌
Didanosine and Hydroxyurea: contraindicated interaction.
最終更新日
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概要
Hydroxyurea combined with didanosine has caused pancreatitis, hepatotoxicity including fatal hepatic failure, and peripheral neuropathy in HIV patients. The overlapping toxicities make the combination dangerous.
この相互作用をわかりやすく説明すると
Didanosine and Hydroxyurea are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Didanosine belongs to Anti Virals; Hydroxyurea belongs to Miscellaneous.
なぜ起こるのか
Additive pancreatic, hepatic and neurotoxicity; the exact mechanism is not fully established.
対処法
Do not combine; choose a different antiretroviral. If exposure has occurred, monitor for pancreatitis, liver injury and neuropathy and stop the agents if signs appear.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DidanosineとHydroxyureaの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Didanosineのその他の相互作用
Hydroxyureaのその他の相互作用
よくある質問
Can I take Didanosine with Hydroxyurea?
MediHelp rates the interaction as contraindicated. Didanosine and Hydroxyurea are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydroxyurea combined with didanosine has caused pancreatitis, hepatotoxicity including fatal hepatic failure, and peripheral neuropathy in HIV patients. The overlapping toxicities make the combination dangerous.
How serious is the interaction between Didanosine and Hydroxyurea?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose a different antiretroviral. If exposure has occurred, monitor for pancreatitis, liver injury and neuropathy and stop the agents if signs appear.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Ribavirin. The full list is on the Didanosine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
