相互作用
Dolutegravir + Zinc
重症度: 中等度
Dolutegravir and Zinc: moderate interaction.
最終更新日
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概要
Zinc supplements taken with dolutegravir can bind the drug in the gut and reduce its absorption. This may lower dolutegravir levels and weaken virologic control.
この相互作用をわかりやすく説明すると
Dolutegravir and Zinc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolutegravir belongs to Anti Virals; Zinc belongs to Gastrointestinal Tract.
なぜ起こるのか
Chelation of dolutegravir by zinc cations in the gastrointestinal tract reduces absorption.
対処法
Give dolutegravir at least 2 hours before or 6 hours after zinc supplements, or take them together with a meal.
薬剤師に尋ねること
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、DolutegravirとZincの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Dolutegravirのその他の相互作用
Zincのその他の相互作用
よくある質問
Can I take Dolutegravir with Zinc?
MediHelp rates the interaction as moderate. Dolutegravir and Zinc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zinc supplements taken with dolutegravir can bind the drug in the gut and reduce its absorption. This may lower dolutegravir levels and weaken virologic control.
How serious is the interaction between Dolutegravir and Zinc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give dolutegravir at least 2 hours before or 6 hours after zinc supplements, or take them together with a meal.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Atidarsagene autotemcel. The full list is on the Dolutegravir page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
