相互作用
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital
重症度: 併用禁忌
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Secobarbital: contraindicated interaction.
最終更新日
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概要
Barbiturates induce CYP3A4 and can reduce elvitegravir and cobicistat exposure. This may cause loss of virologic control and resistance. The combination should be avoided.
この相互作用をわかりやすく説明すると
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Secobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Barbiturate-mediated CYP3A4 induction accelerates elvitegravir and cobicistat metabolism.
対処法
Do not coadminister. Use a non-inducing sedative, or change the antiretroviral regimen.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Elvitegravir / cobicistat / emtricitabine / tenofovir dfとSecobarbitalの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Secobarbitalのその他の相互作用
よくある質問
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Secobarbital?
MediHelp rates the interaction as contraindicated. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Secobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Barbiturates induce CYP3A4 and can reduce elvitegravir and cobicistat exposure. This may cause loss of virologic control and resistance. The combination should be avoided.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Secobarbital?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Use a non-inducing sedative, or change the antiretroviral regimen.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
