相互作用
Enalapril-hydrochlorothiazide + Sacubitril / valsartan
重症度: 併用禁忌
Enalapril-hydrochlorothiazide and Sacubitril / valsartan: contraindicated interaction.
最終更新日
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概要
Combining an ACE inhibitor with sacubitril/valsartan markedly raises the risk of angioedema due to reduced bradykinin breakdown. Additive hypotension, hyperkalemia and renal effects from RAS blockade also occur.
この相互作用をわかりやすく説明すると
Enalapril-hydrochlorothiazide and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Concurrent inhibition of neprilysin and ACE reduces bradykinin degradation, causing bradykinin-mediated angioedema.
対処法
Do not coadminister; separate by at least 36 hours when switching in either direction.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Enalapril-hydrochlorothiazideとSacubitril / valsartanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Enalapril-hydrochlorothiazideのその他の相互作用
よくある質問
Can I take Enalapril-hydrochlorothiazide with Sacubitril / valsartan?
MediHelp rates the interaction as contraindicated. Enalapril-hydrochlorothiazide and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an ACE inhibitor with sacubitril/valsartan markedly raises the risk of angioedema due to reduced bradykinin breakdown. Additive hypotension, hyperkalemia and renal effects from RAS blockade also occur.
How serious is the interaction between Enalapril-hydrochlorothiazide and Sacubitril / valsartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; separate by at least 36 hours when switching in either direction.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
