相互作用
Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir
重症度: 併用禁忌
Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir and dasabuvir: contraindicated interaction.
最終更新日
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概要
Coadministration of ethinyl estradiol-containing products with this HCV regimen has produced marked ALT elevations in clinical trials. The risk of liver injury makes the combination unsuitable. Drospirenone also carries a hyperkalemia concern with strong CYP3A inhibitors such as ritonavir.
この相互作用をわかりやすく説明すると
Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
The mechanism of the ALT elevation is not established; ritonavir also inhibits CYP3A4 and may raise drospirenone exposure.
対処法
Avoid ethinyl estradiol-containing contraceptives before and during this regimen. Switch to a progestin-only or non-hormonal method and restart estrogen only after the regimen has been completed, as advised in the labeling.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、Ethinyl estradiol-drospirenoneとOmbitasvir / paritaprevir / ritonavir and dasabuvirの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ethinyl estradiol-drospirenoneのその他の相互作用
- Ethinyl estradiol-drospirenone + Fezolinetant 併用禁忌
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir 併用禁忌
- Ethinyl estradiol-drospirenone + Tranexamic acid 併用禁忌
- Aminocaproic acid + Ethinyl estradiol-drospirenone 重大
- Amobarbital + Ethinyl estradiol-drospirenone 重大
- Anastrozole + Ethinyl estradiol-drospirenone 重大
よくある質問
Can I take Ethinyl estradiol-drospirenone with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as contraindicated. Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Coadministration of ethinyl estradiol-containing products with this HCV regimen has produced marked ALT elevations in clinical trials. The risk of liver injury makes the combination unsuitable. Drospirenone also carries a hyperkalemia concern with strong CYP3A inhibitors such as ritonavir.
How serious is the interaction between Ethinyl estradiol-drospirenone and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ethinyl estradiol-containing contraceptives before and during this regimen. Switch to a progestin-only or non-hormonal method and restart estrogen only after the regimen has been completed, as advised in the labeling.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Tranexamic acid. The full list is on the Ethinyl estradiol-drospirenone page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
