相互作用
Fentanyl + Olanzapine / samidorphan
重症度: 併用禁忌
Fentanyl and Olanzapine / samidorphan: contraindicated interaction.
最終更新日
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概要
Samidorphan blocks opioid receptors, reducing fentanyl's analgesic effect and potentially precipitating withdrawal in opioid-dependent patients. Attempts to overcome the blockade with higher opioid doses risk overdose.
この相互作用をわかりやすく説明すると
Fentanyl and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Samidorphan is a mu-opioid receptor antagonist that opposes fentanyl's agonist effects.
対処法
Ensure an opioid-free interval of at least 7 days for short-acting and 14 days for long-acting opioids before starting. Use an alternative antipsychotic in patients who need opioids.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、FentanylとOlanzapine / samidorphanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Fentanylのその他の相互作用
よくある質問
Can I take Fentanyl with Olanzapine / samidorphan?
MediHelp rates the interaction as contraindicated. Fentanyl and Olanzapine / samidorphan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan blocks opioid receptors, reducing fentanyl's analgesic effect and potentially precipitating withdrawal in opioid-dependent patients. Attempts to overcome the blockade with higher opioid doses risk overdose.
How serious is the interaction between Fentanyl and Olanzapine / samidorphan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure an opioid-free interval of at least 7 days for short-acting and 14 days for long-acting opioids before starting. Use an alternative antipsychotic in patients who need opioids.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Phenelzine. The full list is on the Fentanyl page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
