相互作用
Ledipasvir-sofosbuvir + Phenobarbital
重症度: 併用禁忌
Ledipasvir-sofosbuvir and Phenobarbital: contraindicated interaction.
最終更新日
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概要
Phenobarbital is an inducer of P-glycoprotein and metabolic enzymes and is expected to lower sofosbuvir and ledipasvir concentrations. This may reduce antiviral efficacy and risk treatment failure.
この相互作用をわかりやすく説明すると
Ledipasvir-sofosbuvir and Phenobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Phenobarbital induces intestinal P-glycoprotein, reducing absorption and plasma concentrations of sofosbuvir and ledipasvir.
対処法
Avoid the combination. Use a non-inducing anticonvulsant alternative before and during hepatitis C therapy, with neurology input.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Ledipasvir-sofosbuvirとPhenobarbitalの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Ledipasvir-sofosbuvirのその他の相互作用
よくある質問
Can I take Ledipasvir-sofosbuvir with Phenobarbital?
MediHelp rates the interaction as contraindicated. Ledipasvir-sofosbuvir and Phenobarbital are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenobarbital is an inducer of P-glycoprotein and metabolic enzymes and is expected to lower sofosbuvir and ledipasvir concentrations. This may reduce antiviral efficacy and risk treatment failure.
How serious is the interaction between Ledipasvir-sofosbuvir and Phenobarbital?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Use a non-inducing anticonvulsant alternative before and during hepatitis C therapy, with neurology input.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenytoin, Rifampin. The full list is on the Ledipasvir-sofosbuvir page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
