相互作用
Lisinopril + Protein a column
重症度: 併用禁忌
Lisinopril and Protein a column: contraindicated interaction.
最終更新日
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概要
Patients taking ACE inhibitors who undergo immunoadsorption with a protein A column have had severe anaphylactoid reactions with flushing, hypotension, and dyspnea. Bradykinin accumulation is thought to be responsible.
この相互作用をわかりやすく説明すると
Lisinopril and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
ACE inhibition reduces bradykinin breakdown, and column-activated bradykinin generation leads to anaphylactoid reactions.
対処法
Stop lisinopril well before the procedure (labeling suggests about 72 hours) and use an alternative antihypertensive. Consider a different apheresis membrane if the ACE inhibitor cannot be stopped.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
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アカウントを作成してPro+トライアルを始めると、LisinoprilとProtein a columnの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Lisinoprilのその他の相互作用
よくある質問
Can I take Lisinopril with Protein a column?
MediHelp rates the interaction as contraindicated. Lisinopril and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Patients taking ACE inhibitors who undergo immunoadsorption with a protein A column have had severe anaphylactoid reactions with flushing, hypotension, and dyspnea. Bradykinin accumulation is thought to be responsible.
How serious is the interaction between Lisinopril and Protein a column?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop lisinopril well before the procedure (labeling suggests about 72 hours) and use an alternative antihypertensive. Consider a different apheresis membrane if the ACE inhibitor cannot be stopped.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Lisinopril page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
