相互作用
Lorlatinib + Lumacaftor / ivacaftor
重症度: 併用禁忌
Lorlatinib and Lumacaftor / ivacaftor: contraindicated interaction.
最終更新日
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概要
Lumacaftor is a strong CYP3A inducer and can lower lorlatinib concentrations. This risks reduced antitumor effect and liver toxicity.
この相互作用をわかりやすく説明すると
Lorlatinib and Lumacaftor / ivacaftor are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Induction of CYP3A4 by lumacaftor increases lorlatinib metabolism.
対処法
Avoid the combination and use alternatives. Allow adequate washout of the inducer before starting lorlatinib.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、LorlatinibとLumacaftor / ivacaftorの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Lorlatinibのその他の相互作用
よくある質問
Can I take Lorlatinib with Lumacaftor / ivacaftor?
MediHelp rates the interaction as contraindicated. Lorlatinib and Lumacaftor / ivacaftor are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lumacaftor is a strong CYP3A inducer and can lower lorlatinib concentrations. This risks reduced antitumor effect and liver toxicity.
How serious is the interaction between Lorlatinib and Lumacaftor / ivacaftor?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use alternatives. Allow adequate washout of the inducer before starting lorlatinib.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
