相互作用
Measles vaccine + Melphalan
重症度: 併用禁忌
Measles vaccine and Melphalan: contraindicated interaction.
最終更新日
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概要
Measles vaccine contains live attenuated virus, which can replicate without control in a patient immunosuppressed by melphalan. This can lead to disseminated vaccine-virus disease, and the vaccine response is also reduced.
この相互作用をわかりやすく説明すると
Measles vaccine and Melphalan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
なぜ起こるのか
Chemotherapy-induced immunosuppression allows unchecked replication of live attenuated virus and impairs the vaccine response.
対処法
Avoid live vaccines during melphalan therapy and for at least 3 months after it ends, subject to immune recovery. Give live vaccines at least 4 weeks before starting chemotherapy when possible.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、Measles vaccineとMelphalanの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Melphalanのその他の相互作用
- Adenovirus types 4 and 7 live + Melphalan 併用禁忌
- Bcg vaccine live + Melphalan 併用禁忌
- Influenza virus vaccine quadrivalent intranasal + Melphalan 併用禁忌
- Measles mumps and rubella vaccine live + Melphalan 併用禁忌
- Measles mumps and rubella vaccine + Melphalan 併用禁忌
- Measles mumps rubella and varicella vaccine live + Melphalan 併用禁忌
よくある質問
Can I take Measles vaccine with Melphalan?
MediHelp rates the interaction as contraindicated. Measles vaccine and Melphalan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Measles vaccine contains live attenuated virus, which can replicate without control in a patient immunosuppressed by melphalan. This can lead to disseminated vaccine-virus disease, and the vaccine response is also reduced.
How serious is the interaction between Measles vaccine and Melphalan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during melphalan therapy and for at least 3 months after it ends, subject to immune recovery. Give live vaccines at least 4 weeks before starting chemotherapy when possible.
What other medicines interact with Melphalan?
MediHelp also lists interactions of Melphalan with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Melphalan page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
