相互作用
Mefloquine + Pimozide
重症度: 併用禁忌
Mefloquine and Pimozide: contraindicated interaction.
最終更新日
医療従事者向け・参照専用。このページは簡潔な要約であり、医学的助言ではなく、公式の添付文書や臨床判断に代わるものではありません。処方・調剤の前に必ず確認してください。
このページの臨床コンテンツは英語でのみ提供されています。
概要
Pimozide is a potent QT-prolonging antipsychotic, and mefloquine further lengthens the QT interval. The combination carries a high risk of torsades de pointes and sudden cardiac death.
この相互作用をわかりやすく説明すると
Mefloquine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Mefloquine belongs to Anti Parasitic; Pimozide belongs to Central Nervous System.
なぜ起こるのか
Additive QT prolongation through cardiac potassium channel blockade.
対処法
Do not use together; choose an antimalarial without QT effects. If mefloquine has been taken recently, allow for its long half-life before starting pimozide.
薬剤師に尋ねること
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+会員向け
ページ全体を見る
アカウントを作成してPro+トライアルを始めると、MefloquineとPimozideの臨床対応の詳細なアドバイス、追加の注記、エビデンスの詳細、処方全体を対象とした相互作用チェッカーを利用できます。
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
WebでPro+を14日間無料でお試し。カード登録不要。
Mefloquineのその他の相互作用
Pimozideのその他の相互作用
よくある質問
Can I take Mefloquine with Pimozide?
MediHelp rates the interaction as contraindicated. Mefloquine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pimozide is a potent QT-prolonging antipsychotic, and mefloquine further lengthens the QT interval. The combination carries a high risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Mefloquine and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose an antimalarial without QT effects. If mefloquine has been taken recently, allow for its long half-life before starting pimozide.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
完全なモノグラフ、用量、相互作用チェッカーはMediHelpアプリで
MediHelpアプリで、完全なリファレンスを開き、複数薬剤の相互作用をチェックし、用量ツールを利用できます。
