Referência de medicamentos
Collagenase
Collagenase is a medicine in the class miscellaneous. It is used for burns.
- Classe do medicamento: Miscellaneous
- Indicado para: burns
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Pontos-chave
- Classe do medicamento
- Miscellaneous
- Interações conhecidas
- 1 (Moderada: 1)
Para que é usado
Como funciona
Collagenase digests collagen in the physiological pH and temperature range, removing detritus and contributing to granulation tissue formation and epithelization. Collagen in healthy tissue or new granulation tissue is not attacked.
Dose habitual em adultos (resumo da bula)
Debridement of chronic dermal ulcers and severely burned areas: apply topically to the wound once daily, or more often if the dressing becomes soiled; stop when debridement is complete and granulation tissue is well established
Gravidez e amamentação
- Gravidez
- Unknown Injection (Xiaflex): blood levels are undetectable after injection; animal studies showed no harm; human case data are insufficient. Ointment (Santyl): not meaningfully absorbed. Use if needed; some labels advise postponing Xiaflex until after pregnancy.
- Amamentação
- Safe No milk data. Blood levels are undetectable after Xiaflex injection and the ointment is not meaningfully absorbed, so infant exposure is unlikely. US label: weigh benefits. Do not apply ointment to the breast.
Efeitos adversos relatados
- Transient erythema of surrounding tissue
- Systemic hypersensitivity (one case reported)
Contraindicações
- Local or systemic hypersensitivity to collagenase
Quem deve ter cuidado
- Enzyme activity is best at pH 6 to 8; higher or lower pH reduces activity.
- Detergents and heavy metal ions (mercury, silver) in some antiseptics reduce activity. Cleanse the site with repeated normal saline washings first. Avoid soaks containing metal ions or acidic solutions.
- Monitor debilitated patients closely for systemic bacterial infection, as debriding enzymes may theoretically increase the risk of bacteremia.
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Principais interações (1)
- Collagenase + Silver sulfadiazine Moderate
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- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
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Outros medicamentos desta classe
Perguntas frequentes
What is Collagenase used for?
Collagenase is a medicine in the class miscellaneous. It is used for Burns, Skin ulcers.
What side effects have been reported with Collagenase?
Transient erythema of surrounding tissue, Systemic hypersensitivity (one case reported).
Can Collagenase be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Injection (Xiaflex): blood levels are undetectable after injection; animal studies showed no harm; human case data are insufficient. Ointment (Santyl): not meaningfully absorbed. Use if needed; some labels advise postponing Xiaflex until after pregnancy. Breastfeeding: Safe. No milk data. Blood levels are undetectable after Xiaflex injection and the ointment is not meaningfully absorbed, so infant exposure is unlikely. US label: weigh benefits. Do not apply ointment to the breast.
What does Collagenase interact with?
MediHelp lists 1 known interactions for Collagenase. Moderate: 1. The most serious include Silver sulfadiazine.
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