Referência de medicamentos
Diazoxide
Diazoxide is a medicine in the class miscellaneous. It is used for hypoglycemia.
- Classe do medicamento: Miscellaneous
- Indicado para: hypoglycemia
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Pontos-chave
- Classe do medicamento
- Miscellaneous
- Formas farmacêuticas comuns
- suspensão oral
- Concentrações comuns
- 50 mg/ml
- Interações conhecidas
- 40 (Grave: 10 · Moderada: 30)
- Nomes comerciais
- 1
- Países e mercados
- 1
Para que é usado
Como funciona
Produces a dose-related rise in blood glucose, mainly by inhibiting insulin release from the pancreas, with an additional extrapancreatic effect.
Dose habitual em adultos (resumo da bula)
Hypoglycemia due to hyperinsulinism (adults and children): starting 3 mg/kg/day orally, divided into 3 equal doses every 8 hours or 2 equal doses every 12 hours; titrate to a maximum of 8 mg/kg/day; refractory hypoglycemia may need higher doses
Gravidez e amamentação
- Gravidez
- Unsafe Case reports are too few to assess birth-defect risk. It crosses the placenta: use before delivery has caused high blood sugar, hair loss and excess body hair in newborns, and labels warn of jaundice and low platelets. Use only if the mother's benefit outweighs the risk.
- Amamentação
- Unknown Present in human milk; no data on infant effects or milk supply. US labels: weigh breastfeeding against the mother's need (older label: choose one). If used, monitor the infant's blood glucose, especially in the newborn period.
Efeitos adversos relatados
- Sodium and fluid retention
- Hirsutism (lanugo type)
- Hyperglycemia or glycosuria
- Anorexia, nausea, vomiting, abdominal pain, diarrhea
- Tachycardia and palpitations
- Increased serum uric acid
Contraindicações
- Functional hypoglycemia
- Hypersensitivity to diazoxide, its excipients, or other thiazides
Quem deve ter cuidado
- Fluid retention from antidiuretic effect may precipitate congestive heart failure in patients with compromised cardiac reserve.
- Ketoacidosis and nonketotic hyperosmolar coma reported, usually during intercurrent illness; long half-life requires prolonged surveillance; patients should monitor urine glucose and ketones.
- Pulmonary hypertension reported in neonates and infants; monitor and discontinue if suspected.
Informe ao farmacêutico ou ao médico sobre gravidez ou amamentação, doença renal ou hepática, alergias e todos os outros medicamentos ou suplementos que você usa.
Principais interações (40)
- Alogliptin-metformin + Diazoxide Major
- Canagliflozin-metformin + Diazoxide Major
- Diazoxide + Empagliflozin-metformin Major
- Diazoxide + Glipizide-metformin Major
- Diazoxide + Glyburide-metformin Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-liraglutide Major
- Diazoxide + Linagliptin-metformin Major
- Diazoxide + Metformin-pioglitazone Major
- Diazoxide + Metformin-sitagliptin Major
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- Paediatric dosing
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Perguntas frequentes
What is Diazoxide used for?
Diazoxide is a medicine in the class miscellaneous. It is used for Hypoglycemia.
What side effects have been reported with Diazoxide?
Sodium and fluid retention, Hirsutism (lanugo type), Hyperglycemia or glycosuria, Anorexia, nausea, vomiting, abdominal pain, diarrhea, Tachycardia and palpitations, Increased serum uric acid.
Can Diazoxide be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Case reports are too few to assess birth-defect risk. It crosses the placenta: use before delivery has caused high blood sugar, hair loss and excess body hair in newborns, and labels warn of jaundice and low platelets. Use only if the mother's benefit outweighs the risk. Breastfeeding: Unknown. Present in human milk; no data on infant effects or milk supply. US labels: weigh breastfeeding against the mother's need (older label: choose one). If used, monitor the infant's blood glucose, especially in the newborn period.
What does Diazoxide interact with?
MediHelp lists 40 known interactions for Diazoxide. Major: 10 · Moderate: 30. The most serious include Alogliptin-metformin, Canagliflozin-metformin, Empagliflozin-metformin.
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