Referência de medicamentos
Nelarabine
Nelarabine is a medicine in the class oncology. It is used for acute lymphocytic leukemia.
- Classe do medicamento: Oncology
- Indicado para: acute lymphocytic leukemia
Última atualização Fontes: US FDA label
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Pontos-chave
- Classe do medicamento
- Oncology
- Código ATC
- L01BB07
- Formas farmacêuticas comuns
- injeção
- Concentrações comuns
- 5 mg/ml
- Interações conhecidas
- 9 (Grave: 4 · Moderada: 4 · Leve: 1)
- Nomes comerciais
- 2
- Países e mercados
- 2
Para que é usado
Como funciona
Nelarabine is a prodrug of ara-G, a nucleoside metabolic inhibitor. It is demethylated by ADA to ara-G and converted to the active triphosphate ara-GTP, which is incorporated into DNA, inhibiting DNA synthesis and causing cell death.
Dose habitual em adultos (resumo da bula)
Relapsed or refractory T-ALL/T-LBL: 1,500 mg/m2 by intravenous infusion over 2 hours on Days 1, 3, and 5, repeated every 21 days; administer undiluted
Gravidez e amamentação
- Gravidez
- Unsafe Can cause fetal harm: it was teratogenic in rabbits at doses below the human dose; human data are too limited. Check pregnancy status before starting; women should use effective contraception during treatment and men should use condoms during and for 3 months after.
- Amamentação
- Unsafe No data on milk levels. e-lactancia: incompatible; a small, poorly protein-bound molecule likely to pass into milk. US label: do not breastfeed during treatment because of possible serious infant reactions, such as severe nerve toxicity.
Efeitos adversos relatados
- Anemia
- Thrombocytopenia
- Neutropenia
- Fatigue
- Nausea
- Cough
Advertências de caixa preta
- Severe neurologic adverse reactions have occurred, including altered mental states with severe somnolence, convulsions, peripheral neuropathy from numbness and paresthesias to weakness and paralysis, demyelination, and ascending neuropathy similar to Guillain-Barré syndrome. Full recovery has not always occurred after stopping therapy. Monitor frequently for neurologic toxicity and discontinue for CTCAE Grade 2 or greater neurologic reactions.
Quem deve ter cuidado
- Neurologic toxicity: monitor during and for at least 24 hours after treatment. Prior or concurrent intrathecal chemotherapy or prior craniospinal irradiation may increase risk.
- Hematologic toxicity: leukopenia, thrombocytopenia, anemia and neutropenia; monitor complete blood counts including platelets regularly.
- Embryo-fetal toxicity: can cause fetal harm; verify pregnancy status, use effective contraception, and males should use condoms during treatment and for 3 months after the last dose.
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Principais interações (9)
- Deferiprone + Nelarabine Major
- Nelarabine + Pentostatin Major
- Nelarabine + Siponimod Major
- Nelarabine + Tofacitinib Major
- Denosumab + Nelarabine Moderate
- Fingolimod + Nelarabine Moderate
- Hydroxyurea + Nelarabine Moderate
- Nelarabine + Trastuzumab Moderate
- Nelarabine + Vitamin e Minor
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Outros medicamentos desta classe
Perguntas frequentes
What is Nelarabine used for?
Nelarabine is a medicine in the class oncology. It is used for Acute lymphocytic leukemia, Lymphoma.
What side effects have been reported with Nelarabine?
Anemia, Thrombocytopenia, Neutropenia, Fatigue, Nausea, Cough. Serious warning: Severe neurologic adverse reactions have occurred, including altered mental states with severe somnolence, convulsions, peripheral neuropathy from numbness and paresthesias to weakness and paralysis, demyelination, and ascending neuropathy similar to Guillain-Barré syndrome.
Can Nelarabine be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm: it was teratogenic in rabbits at doses below the human dose; human data are too limited. Check pregnancy status before starting; women should use effective contraception during treatment and men should use condoms during and for 3 months after. Breastfeeding: Unsafe. No data on milk levels. e-lactancia: incompatible; a small, poorly protein-bound molecule likely to pass into milk. US label: do not breastfeed during treatment because of possible serious infant reactions, such as severe nerve toxicity.
What does Nelarabine interact with?
MediHelp lists 9 known interactions for Nelarabine. Major: 4 · Moderate: 4 · Minor: 1. The most serious include Deferiprone, Pentostatin, Siponimod.
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