Referência de medicamentos
Valbenazine
Valbenazine is a medicine in the class central nervous system. It is used for tardive dyskinesia.
- Classe do medicamento: Central Nervous System
- Indicado para: tardive dyskinesia
Última atualização Fontes: US FDA label
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Pontos-chave
- Classe do medicamento
- Central Nervous System
- Formas farmacêuticas comuns
- cápsula
- Interações conhecidas
- 135 (Contraindicada: 2 · Grave: 24 · Moderada: 105 · Leve: 4)
- Nomes comerciais
- 2
- Países e mercados
- 1
Para que é usado
Como funciona
Mechanism in tardive dyskinesia and Huntington's chorea is unclear, but thought to be mediated through reversible inhibition of vesicular monoamine transporter 2 (VMAT2), which regulates monoamine uptake from the cytoplasm into synaptic vesicles.
Dose habitual em adultos (resumo da bula)
Tardive dyskinesia: initial 40 mg orally once daily; after one week increase to the recommended 80 mg once daily; 40 mg or 60 mg once daily may be considered depending on response and tolerability.
Gravidez e amamentação
- Gravidez
- Unsafe May cause fetal harm; human data insufficient. Animal studies showed increased stillbirths and postnatal pup mortality at doses below the MRHD. Advise pregnant women of potential fetal risk.
- Amamentação
- Unsafe No human milk data; advise women not to breastfeed during treatment and for 5 days after the final dose.
Efeitos adversos relatados
- Somnolence (somnolence, fatigue, sedation)
- Anticholinergic effects
- Balance disorders/fall
- Headache
- Akathisia
- Vomiting
Advertências de caixa preta
- VMAT2 inhibitors, including valbenazine, can increase the risk of depression and suicidal thoughts and behavior in patients with Huntington's disease. Balance these risks against the clinical need for chorea treatment, monitor closely for emergence or worsening of depression, suicidality or unusual behavior changes, inform patients, caregivers and families to report concerning behaviors promptly, and use particular caution in patients with a history of depression or prior suicide attempts or ideation.
Contraindicações
- History of hypersensitivity to valbenazine or any components of the product.
Quem deve ter cuidado
- Hypersensitivity reactions including angioedema (involving larynx, glottis, lips, eyelids) can occur and may be fatal; discontinue if they occur.
- Somnolence and sedation: avoid driving or operating hazardous machinery until effects are known.
- QT prolongation: may be clinically significant with strong CYP2D6/CYP3A4 inhibitors or in CYP2D6 poor metabolizers; avoid in congenital long QT syndrome or arrhythmias associated with prolonged QT.
Informe ao farmacêutico ou ao médico sobre gravidez ou amamentação, doença renal ou hepática, alergias e todos os outros medicamentos ou suplementos que você usa.
Principais interações (135)
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
- Cisapride + Valbenazine Major
- Clarithromycin + Valbenazine Major
- Dronedarone + Valbenazine Major
- Enzalutamide + Valbenazine Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Perguntas frequentes
What is Valbenazine used for?
Valbenazine is a medicine in the class central nervous system. It is used for Tardive dyskinesia.
What side effects have been reported with Valbenazine?
Somnolence (somnolence, fatigue, sedation), Anticholinergic effects, Balance disorders/fall, Headache, Akathisia, Vomiting. Serious warning: VMAT2 inhibitors, including valbenazine, can increase the risk of depression and suicidal thoughts and behavior in patients with Huntington's disease.
Can Valbenazine be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. May cause fetal harm; human data insufficient. Animal studies showed increased stillbirths and postnatal pup mortality at doses below the MRHD. Advise pregnant women of potential fetal risk. Breastfeeding: Unsafe. No human milk data; advise women not to breastfeed during treatment and for 5 days after the final dose.
What does Valbenazine interact with?
MediHelp lists 135 known interactions for Valbenazine. Contraindicated: 2 · Major: 24 · Moderate: 105 · Minor: 4. The most serious include Deutetrabenazine, Tranylcypromine, Amiodarone.
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