Interações medicamentosas
Aceclofenac + Probenecid
Gravidade: Moderada
Aceclofenac and Probenecid: moderate interaction.
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Resumo
Probenecid inhibits renal organic anion transport and can raise NSAID concentrations, including those of aceclofenac and its metabolites. This may increase NSAID adverse effects such as gastrointestinal and renal toxicity.
O que esta interação significa em palavras simples
Aceclofenac and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aceclofenac belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
Por que acontece
Probenecid inhibits OAT-mediated renal tubular secretion of aceclofenac and its metabolites.
O que fazer
Use the lowest effective aceclofenac dose and monitor for GI bleeding and renal function. Reduce the NSAID dose if adverse effects appear.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Probenecid
- Ketorolac intranasal + Probenecid Contraindicada
- Ketorolac + Probenecid Contraindicada
- Baricitinib + Probenecid Grave
- Ceftazidime / avibactam + Probenecid Grave
- Methotrexate + Probenecid Grave
- Pralatrexate + Probenecid Grave
Outras interações de Aceclofenac
Perguntas frequentes
Can I take Aceclofenac with Probenecid?
MediHelp rates the interaction as moderate. Aceclofenac and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid inhibits renal organic anion transport and can raise NSAID concentrations, including those of aceclofenac and its metabolites. This may increase NSAID adverse effects such as gastrointestinal and renal toxicity.
How serious is the interaction between Aceclofenac and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective aceclofenac dose and monitor for GI bleeding and renal function. Reduce the NSAID dose if adverse effects appear.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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