Interações medicamentosas
Acemetacin + Amiloride
Gravidade: Grave
Acemetacin and Amiloride: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Acemetacin, an NSAID, can reduce renal prostaglandins and impair potassium excretion, adding to amiloride's potassium retention. It may also reduce the diuretic and antihypertensive effects and raise the risk of acute kidney injury.
O que esta interação significa em palavras simples
Acemetacin and Amiloride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
NSAID-induced suppression of renin-aldosterone and renal prostaglandins reduces potassium and sodium excretion, combined with amiloride's ENaC blockade.
O que fazer
Avoid the combination where possible, especially in CKD or the elderly. If needed, monitor potassium, creatinine and blood pressure closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Amiloride
- Amiloride + Eplerenone Contraindicada
- Amiloride + Spironolactone Contraindicada
- Amiloride + Triamterene Contraindicada
- Aceclofenac + Amiloride Grave
- Amiloride + Amlodipine-benazepril Grave
- Amiloride + Amlodipine-hydrochlorothiazide-valsartan Grave
Perguntas frequentes
Can I take Acemetacin with Amiloride?
MediHelp rates the interaction as major. Acemetacin and Amiloride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Acemetacin, an NSAID, can reduce renal prostaglandins and impair potassium excretion, adding to amiloride's potassium retention. It may also reduce the diuretic and antihypertensive effects and raise the risk of acute kidney injury.
How serious is the interaction between Acemetacin and Amiloride?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, especially in CKD or the elderly. If needed, monitor potassium, creatinine and blood pressure closely.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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