Interações medicamentosas
Acetylsalicylic acid + Caplacizumab
Gravidade: Grave
Acetylsalicylic acid and Caplacizumab: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Caplacizumab inhibits von Willebrand factor-mediated platelet adhesion, and aspirin inhibits platelet aggregation, so combined use increases the risk of bleeding. Aspirin is sometimes used alongside caplacizumab in aTTP, but bleeding such as epistaxis and gingival bleeding is more likely.
O que esta interação significa em palavras simples
Acetylsalicylic acid and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acetylsalicylic acid belongs to Musculoskeletal; Caplacizumab belongs to Cardiovascular.
Por que acontece
Additive impairment of platelet function and primary hemostasis via different pathways.
O que fazer
Monitor closely for bleeding and hold caplacizumab before any invasive procedure. Use aspirin only when clearly indicated and review the need if bleeding occurs.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicada
- Acetylsalicylic acid + Ketorolac intranasal Contraindicada
- Abciximab + Acetylsalicylic acid Grave
- Acemetacin + Acetylsalicylic acid Grave
- Acetazolamide + Acetylsalicylic acid Grave
- Acetylsalicylic acid + Alteplase Grave
Outras interações de Caplacizumab
Perguntas frequentes
Can I take Acetylsalicylic acid with Caplacizumab?
MediHelp rates the interaction as major. Acetylsalicylic acid and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab inhibits von Willebrand factor-mediated platelet adhesion, and aspirin inhibits platelet aggregation, so combined use increases the risk of bleeding. Aspirin is sometimes used alongside caplacizumab in aTTP, but bleeding such as epistaxis and gingival bleeding is more likely.
How serious is the interaction between Acetylsalicylic acid and Caplacizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for bleeding and hold caplacizumab before any invasive procedure. Use aspirin only when clearly indicated and review the need if bleeding occurs.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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