Interações medicamentosas
Acetylsalicylic acid + Lesinurad
Gravidade: Moderada
Acetylsalicylic acid and Lesinurad: moderate interaction.
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Resumo
High-dose aspirin may reduce the urate-lowering effect of lesinurad, whereas low-dose aspirin for cardiovascular prevention does not appear to do so. The importance depends on the aspirin dose used.
O que esta interação significa em palavras simples
Acetylsalicylic acid and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Lesinurad belongs to Genitourinary.
Por que acontece
Salicylates interfere with renal urate handling at the tubular level, and this may counteract the uricosuric effect, though the exact mechanism is not firmly established.
O que fazer
Keep aspirin at cardioprotective doses (325 mg/day or less) when combined with lesinurad, and avoid analgesic anti-inflammatory aspirin doses. Monitor serum uric acid.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicada
- Acetylsalicylic acid + Ketorolac intranasal Contraindicada
- Abciximab + Acetylsalicylic acid Grave
- Acemetacin + Acetylsalicylic acid Grave
- Acetazolamide + Acetylsalicylic acid Grave
- Acetylsalicylic acid + Alteplase Grave
Outras interações de Lesinurad
- Lesinurad + Norethisterone Grave
- Amiodarone + Lesinurad Moderada
- Apalutamide + Lesinurad Moderada
- Desogestrel-ethinyl estradiol + Lesinurad Moderada
- Dienogest / estradiol valerate + Lesinurad Moderada
- Ethinyl estradiol-drospirenone + Lesinurad Moderada
Perguntas frequentes
Can I take Acetylsalicylic acid with Lesinurad?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Lesinurad can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose aspirin may reduce the urate-lowering effect of lesinurad, whereas low-dose aspirin for cardiovascular prevention does not appear to do so. The importance depends on the aspirin dose used.
How serious is the interaction between Acetylsalicylic acid and Lesinurad?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep aspirin at cardioprotective doses (325 mg/day or less) when combined with lesinurad, and avoid analgesic anti-inflammatory aspirin doses. Monitor serum uric acid.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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