Interações medicamentosas
Alfentanil + Orphenadrin
Gravidade: Grave
Alfentanil and Orphenadrin: major interaction.
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Resumo
Orphenadrine can add to the sedative and respiratory depressant effects of opioids such as alfentanil. This may cause profound drowsiness, respiratory depression and impaired psychomotor performance.
O que esta interação significa em palavras simples
Alfentanil and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive CNS and respiratory depression.
O que fazer
Use the lowest effective doses and monitor sedation level and respiratory rate closely. Reduce the opioid dose as needed.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Orphenadrin
Perguntas frequentes
Can I take Alfentanil with Orphenadrin?
MediHelp rates the interaction as major. Alfentanil and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Orphenadrine can add to the sedative and respiratory depressant effects of opioids such as alfentanil. This may cause profound drowsiness, respiratory depression and impaired psychomotor performance.
How serious is the interaction between Alfentanil and Orphenadrin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation level and respiratory rate closely. Reduce the opioid dose as needed.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Amobarbital, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Orphenadrin page.
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