Interações medicamentosas
Alogliptin-pioglitazone + Bexarotene
Gravidade: Moderada
Alogliptin-pioglitazone and Bexarotene: moderate interaction.
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Resumo
Bexarotene acts on retinoid X receptors, which are the heterodimer partners of PPAR-gamma, and may enhance the insulin-sensitizing effect of pioglitazone. Hypoglycemia is possible, and bexarotene also commonly causes hyperlipidemia and hypothyroidism that can affect metabolic control.
O que esta interação significa em palavras simples
Alogliptin-pioglitazone and Bexarotene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin-pioglitazone belongs to Endocrine; Bexarotene belongs to Oncology.
Por que acontece
Additive activation of the PPAR-gamma/RXR pathway enhances insulin sensitization.
O que fazer
Monitor blood glucose when starting bexarotene and reduce antidiabetic doses if hypoglycemia occurs.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Alogliptin-pioglitazone
Outras interações de Bexarotene
- Bexarotene + Gemfibrozil Grave
- Bexarotene + Lorlatinib Grave
- Amobarbital + Bexarotene Moderada
- Aprepitant + Bexarotene Moderada
- Axitinib + Bexarotene Moderada
- Bexarotene + Bosentan Moderada
Perguntas frequentes
Can I take Alogliptin-pioglitazone with Bexarotene?
MediHelp rates the interaction as moderate. Alogliptin-pioglitazone and Bexarotene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene acts on retinoid X receptors, which are the heterodimer partners of PPAR-gamma, and may enhance the insulin-sensitizing effect of pioglitazone. Hypoglycemia is possible, and bexarotene also commonly causes hyperlipidemia and hypothyroidism that can affect metabolic control.
How serious is the interaction between Alogliptin-pioglitazone and Bexarotene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting bexarotene and reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Alogliptin-pioglitazone?
MediHelp also lists interactions of Alogliptin-pioglitazone with, for example, Gemfibrozil, Insulin aspart, Insulin degludec. The full list is on the Alogliptin-pioglitazone page.
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