Interações medicamentosas
Alosetron + Mexiletine
Gravidade: Grave
Alosetron and Mexiletine: major interaction.
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Resumo
Alosetron is cleared largely by CYP1A2, and inhibitors can raise its levels substantially. Increased exposure raises the risk of ischemic colitis and serious constipation complications. Mexiletine inhibits CYP1A2.
O que esta interação significa em palavras simples
Alosetron and Mexiletine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alosetron belongs to Gastrointestinal Tract; Mexiletine belongs to Cardiovascular.
Por que acontece
Mexiletine inhibits CYP1A2-mediated alosetron metabolism.
O que fazer
Avoid the combination where possible; if used, monitor closely for constipation, abdominal pain and rectal bleeding and stop alosetron promptly if they occur.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Mexiletine
- Fezolinetant + Mexiletine Contraindicada
- Mexiletine + Pimozide Contraindicada
- Amiodarone + Mexiletine Grave
- Clozapine + Mexiletine Grave
- Cobicistat + Mexiletine Grave
- Dofetilide + Mexiletine Grave
Outras interações de Alosetron
- Alosetron + Apomorphine Contraindicada
- Alosetron + Fluvoxamine Contraindicada
- Alosetron + Ciprofloxacin Grave
- Alosetron + Deferasirox Grave
- Alosetron + Eluxadoline Grave
- Alosetron + Ketoconazole Grave
Perguntas frequentes
Can I take Alosetron with Mexiletine?
MediHelp rates the interaction as major. Alosetron and Mexiletine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Alosetron is cleared largely by CYP1A2, and inhibitors can raise its levels substantially. Increased exposure raises the risk of ischemic colitis and serious constipation complications. Mexiletine inhibits CYP1A2.
How serious is the interaction between Alosetron and Mexiletine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor closely for constipation, abdominal pain and rectal bleeding and stop alosetron promptly if they occur.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Amiodarone. The full list is on the Mexiletine page.
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