Interações medicamentosas
Amiodarone + Betaxolol
Gravidade: Grave
Amiodarone and Betaxolol: major interaction.
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Resumo
Both drugs slow sinus rate and AV conduction, and combining them can cause marked bradycardia, AV block or sinus arrest. The risk is highest in patients with existing conduction disease or at initiation.
O que esta interação significa em palavras simples
Amiodarone and Betaxolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Betaxolol belongs to Cardiovascular.
Por que acontece
Additive negative chronotropic and dromotropic effects, with amiodarone's beta-blocking and calcium-channel-like actions adding to beta-1 blockade.
O que fazer
Monitor ECG and heart rate closely when starting the combination and reduce the betaxolol dose if bradycardia occurs. Avoid in patients with significant conduction disease unless a pacemaker is in place.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Betaxolol
- Acebutolol + Betaxolol Grave
- Aldesleukin + Betaxolol Grave
- Amifostine + Betaxolol Grave
- Atenolol-chlorthalidone + Betaxolol Grave
- Atenolol + Betaxolol Grave
- Betaxolol + Bisoprolol Grave
Outras interações de Amiodarone
- Amiodarone + Amisulpride Contraindicada
- Amiodarone + Arsenic trioxide Contraindicada
- Amiodarone + Dofetilide Contraindicada
- Amiodarone + Dronedarone Contraindicada
- Amiodarone + Droperidol Contraindicada
- Amiodarone + Eliglustat Contraindicada
Perguntas frequentes
Can I take Amiodarone with Betaxolol?
MediHelp rates the interaction as major. Amiodarone and Betaxolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs slow sinus rate and AV conduction, and combining them can cause marked bradycardia, AV block or sinus arrest. The risk is highest in patients with existing conduction disease or at initiation.
How serious is the interaction between Amiodarone and Betaxolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate closely when starting the combination and reduce the betaxolol dose if bradycardia occurs. Avoid in patients with significant conduction disease unless a pacemaker is in place.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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