Interações medicamentosas
Armodafinil + Cyclosporine
Gravidade: Grave
Armodafinil and Cyclosporine: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Armodafinil may lower cyclosporine concentrations through enzyme induction. Reduced levels of this narrow-therapeutic-index drug could risk graft rejection.
O que esta interação significa em palavras simples
Armodafinil and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Armodafinil induces CYP3A4, which increases the metabolism of cyclosporine.
O que fazer
Measure cyclosporine trough levels after armodafinil is started or stopped and adjust the dose accordingly. Watch for signs of rejection.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Armodafinil e Cyclosporine, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Armodafinil
Perguntas frequentes
Can I take Armodafinil with Cyclosporine?
MediHelp rates the interaction as major. Armodafinil and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Armodafinil may lower cyclosporine concentrations through enzyme induction. Reduced levels of this narrow-therapeutic-index drug could risk graft rejection.
How serious is the interaction between Armodafinil and Cyclosporine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure cyclosporine trough levels after armodafinil is started or stopped and adjust the dose accordingly. Watch for signs of rejection.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
