Interações medicamentosas
Bortezomib + Idelalisib
Gravidade: Grave
Bortezomib and Idelalisib: major interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Idelalisib is a strong CYP3A inhibitor, and bortezomib is partly cleared by CYP3A4. Strong inhibitors such as ketoconazole have increased bortezomib exposure, so toxicity such as neuropathy and thrombocytopenia may rise. Idelalisib also carries risks of serious infection and diarrhea.
O que esta interação significa em palavras simples
Bortezomib and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bortezomib belongs to Oncology; Idelalisib belongs to Oncology.
Por que acontece
Idelalisib inhibits CYP3A4, reducing bortezomib clearance.
O que fazer
Monitor closely for neuropathy, cytopenias and infection, and consider a bortezomib dose reduction. Choose an alternative to idelalisib if possible.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Bortezomib e Idelalisib, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Referências
Outras interações de Bortezomib
- Apalutamide + Bortezomib Grave
- Bortezomib + Carbamazepine Grave
- Bortezomib + Etrasimod Grave
- Bortezomib + Fosphenytoin Grave
- Bortezomib + Lonafarnib Grave
- Bortezomib + Mitotane Grave
Outras interações de Idelalisib
- Alfuzosin + Idelalisib Contraindicada
- Cisapride + Idelalisib Contraindicada
- Dihydroergotamine + Idelalisib Contraindicada
- Dronedarone + Idelalisib Contraindicada
- Eletriptan + Idelalisib Contraindicada
- Eplerenone + Idelalisib Contraindicada
Perguntas frequentes
Can I take Bortezomib with Idelalisib?
MediHelp rates the interaction as major. Bortezomib and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor, and bortezomib is partly cleared by CYP3A4. Strong inhibitors such as ketoconazole have increased bortezomib exposure, so toxicity such as neuropathy and thrombocytopenia may rise. Idelalisib also carries risks of serious infection and diarrhea.
How serious is the interaction between Bortezomib and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neuropathy, cytopenias and infection, and consider a bortezomib dose reduction. Choose an alternative to idelalisib if possible.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
