Interações medicamentosas
Bosutinib + Chlorpromazine
Gravidade: Grave
Bosutinib and Chlorpromazine: major interaction.
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Resumo
Both drugs can prolong the QT interval, so their combination may increase the risk of torsades de pointes. The risk is higher with electrolyte disturbances, bradycardia, or structural heart disease.
O que esta interação significa em palavras simples
Bosutinib and Chlorpromazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosutinib belongs to Oncology; Chlorpromazine belongs to Central Nervous System.
Por que acontece
Additive QT prolongation through cardiac repolarization effects.
O que fazer
Obtain a baseline ECG and monitor it periodically, and correct potassium and magnesium abnormalities. Consider an alternative to one agent if the QT interval becomes markedly prolonged.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicada
- Chlorpromazine + Dronedarone Contraindicada
- Chlorpromazine + Droperidol Contraindicada
- Chlorpromazine + Ibutilide Contraindicada
- Chlorpromazine + Metrizamide Contraindicada
- Chlorpromazine + Panobinostat Contraindicada
Outras interações de Bosutinib
- Amiodarone + Bosutinib Grave
- Apalutamide + Bosutinib Grave
- Aprepitant + Bosutinib Grave
- Bosentan + Bosutinib Grave
- Bosutinib + Carbamazepine Grave
- Bosutinib + Cisapride Grave
Perguntas frequentes
Can I take Bosutinib with Chlorpromazine?
MediHelp rates the interaction as major. Bosutinib and Chlorpromazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so their combination may increase the risk of torsades de pointes. The risk is higher with electrolyte disturbances, bradycardia, or structural heart disease.
How serious is the interaction between Bosutinib and Chlorpromazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it periodically, and correct potassium and magnesium abnormalities. Consider an alternative to one agent if the QT interval becomes markedly prolonged.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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