Interações medicamentosas
Buprenorphine + Esketamine
Gravidade: Grave
Buprenorphine and Esketamine: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Opioids and esketamine both depress the CNS, and together they raise the risk of profound sedation and respiratory depression. Buprenorphine has a ceiling on respiratory effects, but the risk remains when combined with other depressants.
O que esta interação significa em palavras simples
Buprenorphine and Esketamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Buprenorphine belongs to Musculoskeletal; Esketamine belongs to Central Nervous System.
Por que acontece
Additive CNS and respiratory depression via opioid receptor agonism and NMDA antagonism.
O que fazer
Monitor sedation, respiratory rate and oxygen saturation closely during and after esketamine administration, and use the lowest effective buprenorphine dose.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Esketamine
Outras interações de Buprenorphine
- Alvimopan + Buprenorphine Contraindicada
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicada
- Buprenorphine + Olanzapine / samidorphan Contraindicada
- Buprenorphine + Phenelzine Contraindicada
- Buprenorphine + Pimozide Contraindicada
- Buprenorphine + Thioridazine Contraindicada
Perguntas frequentes
Can I take Buprenorphine with Esketamine?
MediHelp rates the interaction as major. Buprenorphine and Esketamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids and esketamine both depress the CNS, and together they raise the risk of profound sedation and respiratory depression. Buprenorphine has a ceiling on respiratory effects, but the risk remains when combined with other depressants.
How serious is the interaction between Buprenorphine and Esketamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory rate and oxygen saturation closely during and after esketamine administration, and use the lowest effective buprenorphine dose.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
