Interações medicamentosas
Buprenorphine subdermal implant + Eszopiclone
Gravidade: Grave
Buprenorphine subdermal implant and Eszopiclone: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Combining an opioid such as buprenorphine with a sedative-hypnotic raises the risk of profound sedation, respiratory depression, coma and death. Buprenorphine's ceiling effect on respiratory depression is less protective when other depressants are taken.
O que esta interação significa em palavras simples
Buprenorphine subdermal implant and Eszopiclone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive CNS and respiratory depression from opioid receptor agonism plus GABA-A potentiation.
O que fazer
Avoid the combination where possible, or limit eszopiclone dose and duration. Monitor for sedation and respiratory depression and counsel the patient and caregivers.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Eszopiclone
Perguntas frequentes
Can I take Buprenorphine subdermal implant with Eszopiclone?
MediHelp rates the interaction as major. Buprenorphine subdermal implant and Eszopiclone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid such as buprenorphine with a sedative-hypnotic raises the risk of profound sedation, respiratory depression, coma and death. Buprenorphine's ceiling effect on respiratory depression is less protective when other depressants are taken.
How serious is the interaction between Buprenorphine subdermal implant and Eszopiclone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or limit eszopiclone dose and duration. Monitor for sedation and respiratory depression and counsel the patient and caregivers.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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