Interações medicamentosas
Capreomycin + Rocuronium
Gravidade: Grave
Capreomycin and Rocuronium: major interaction.
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Resumo
Capreomycin has neuromuscular blocking activity and can intensify and prolong non-depolarizing blockade from rocuronium. This can result in prolonged paralysis and respiratory insufficiency, especially with renal impairment.
O que esta interação significa em palavras simples
Capreomycin and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive neuromuscular blockade through intrinsic curare-like effects of capreomycin at the neuromuscular junction.
O que fazer
Avoid combining when alternatives exist; otherwise reduce rocuronium dose and monitor with train-of-four until full recovery. Have ventilatory support ready and consider renal function.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Rocuronium
Perguntas frequentes
Can I take Capreomycin with Rocuronium?
MediHelp rates the interaction as major. Capreomycin and Rocuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Capreomycin has neuromuscular blocking activity and can intensify and prolong non-depolarizing blockade from rocuronium. This can result in prolonged paralysis and respiratory insufficiency, especially with renal impairment.
How serious is the interaction between Capreomycin and Rocuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when alternatives exist; otherwise reduce rocuronium dose and monitor with train-of-four until full recovery. Have ventilatory support ready and consider renal function.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Clindamycin. The full list is on the Rocuronium page.
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